(Peer Review + Similarity + Document) Shogaol, Bisdemethoxycurcumin, and Curcuminoid: Potential Zingiber Compounds Against COVID-19

Afrida, Indah Rakhmawati and Fatchiyah, Fatchiyah and Widodo, Nashi and Amin, Mohamad and Djati, Muhammad Sasmito (2021) (Peer Review + Similarity + Document) Shogaol, Bisdemethoxycurcumin, and Curcuminoid: Potential Zingiber Compounds Against COVID-19. Biointerface Research in Applied Chemistry, Rumania.

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Abstract

Coronavirus disease (COVID-19) is a global pandemic in the world. Some treatments, including vaccines and potential drugs, are still developed. This study investigated the bioactive compounds of Zingiber officinale, Kaempferia rotunda, and Curcuma zedoaria as a potential inhibitor for ACE2 and RdRP proteins. Molecular docking was used for screening the bioactive compounds as ACE2 and RdRP inhibitors. Shogaol (CID 5281794), zingerone (CID 31211), chalcone (CID 637760), Ar-turmerone (CID 558221), bisdemothxycurcumin (CID 5315472), and curcuminoid (CID 101341353) interacted with angiotensin-converting enzyme receptor-2/ACE2 (PDB ID 2xd3) and RNA dependent RNA polymerase/RdRP (PDB ID 6xqb), then analyzed using Discovery studio v.19 program. Shogaol, zingerone, chalcone, ar-turmerone, bisdemethoxycurcumin, and curcuminoid bound to ACE2 and RdRP protein in some active sites. Zingerone, chalcone, and ar-turmerone are attached to the ACE-2 and then RdRP protein in similar active sites, suggesting those compounds stabilize the complex ACE-2 and RdRP protein. Shogaol interacted with the RdRP and ACE2 protein amino acid residues in the Shogaol-RdRP+ACE2 complex, indicating shogaol blocks the RdRP-ACE2 interaction. Then, bisdemethoxycurcumin and curcuminoid change the binding sites of ACE2 and RdRP protein when both compounds are bound to RdRP protein. This study suggested that shogaol, bisdemethoxycurcumin, and curcuminoid are potential drugs for COVID-19 prevention.

Item Type:	Peer Review
Uncontrolled Keywords:	ACE2; COVID-19; Curcuma; Ginger; RdRP protein.
Subjects:	500 Natural Science and Mathematics > 570 Biology > 572 Biochemistry
Divisions:	Faculty of Teaching and Education Science > Department of Biology Education (S1)
Depositing User:	INDAH RAKHMAWATI AFRIDA
Contact Email Address:	indahrakhmawatiafrida@unmuhjember.ac.id
Date Deposited:	22 Nov 2021 01:29
Last Modified:	29 Nov 2021 01:41
URI:	http://repository.unmuhjember.ac.id/id/eprint/12216

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