Kurniawan, Hendra (2014) (Similarity) Interleukin-28B Polymorphisms and Response of Chronic Hepatitis C Patients from Indonesia to Pegylated Interferon/Ribavirin Treatment. Journal of Clinical Microbiology, America.
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Abstract
Plasma and peripheral blood mononuclear cells (PBMC) were collected from chronic hepatitis C (CHC) patients in Dr. Saiful Anwar General Hospital, Malang, East Java Province, or a private clinic in Sanglah, Denpasar, Bali Province, Indonesia. All the patients were treated with pegylated interferon (PEG-IFN)-alfa-2a (Pegasys) and ribavirin (RBV). Patients with hepatitis C virus (HCV) genotype 1 were treated for 48 weeks, and patients withHCVgenotype 2 or 3 were treated for 24 weeks. This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.
| Item Type: | Peer Review |
|---|---|
| Subjects: | 600 Technology and Applied Science > 610 Medicine and Health 600 Technology and Applied Science > 610 Medicine and Health > 616 Diseases |
| Divisions: | Faculty of Health > Department of Nursing Science (S1) |
| Depositing User: | Hendra Kurniawan |
| Date Deposited: | 04 Jul 2024 01:14 |
| Last Modified: | 04 Jul 2024 01:14 |
| URI: | http://repository.unmuhjember.ac.id/id/eprint/21199 |
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