Abstract The aim of the study is to find out the effect of the wet cupping
therapy on HDL and IL-6 in hypercholesterolemia patients. Method: This study
was an experimental Quasy study using humans as research subjects. Cupping is
done on 7 points. The sample size of 34 patients. Measurement of HDL dan IL6 using the sandwich ELISA method. Data analysis was performed with the
Wilcoxon SR Test with a significance level of 5% (α = 0.05), the data pretest
compared with the posttest data. Results: HDL cholesterol value pretest 34,84 
5,20 posttest 37,57  3, 25 with p value 0.002. IL-6 value pretest 218,00 
152,48 posttest 289,00  260,00 with p value 0.018. Conclusion: The wet
cupping therapy has a significant effect on increasing the median value of HDL
and IL-6. The inflammatory pathway hasn’t clear yet but has been shown to
increase HDL and IL-6 cholesterol.
Keywords: HDL, LDL, Cholesterol, Blood